Product Informations
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Product No.
BD-PA0002
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Synonyms
PKBB; PRKBB; PKBBETA; RAC-BETA
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Product Name
AKT2 Mouse Monoclonal Antibody
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Category
493
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Gene Name
AKT2
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Recommended Applications
WB,IHC-P,ICC,Elisa
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Reactivity
Human,Rat,Monkey
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Storage Buffer
Ascitic fluid containing 0.03% New type preservative N.
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Immunogen
Purified recombinant fragment of human AKT2 expressed in E. Coli.
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Dilution Ratio
WB 1:500-1:2000, IHC-P 1:200-1:1000, ICC 1:200-1:1000, ELISA 1:10000
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Reference Molecular Weight
60kDa
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Shipping and Storage Conditions
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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Host
Mouse
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Isotype
IgG2b
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Clone No.
1B6
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Lead Time
Three working days
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Clonality
Monoclonal
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Human Gene ID
208
Picture
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Western blot analysis using AKT2 mouse mAb against A431 (1), Jurkat (2), HEK293 (3), A549 (4), MCF-7 (5) and PC-12 (6) cell lysate. |
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Immunofluorescence analysis of PANC-1 (left) and Hela (right) cells using AKT2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. |
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Immunohistochemical analysis of paraffin-embedded human Thymus tissues using anti-AKT2 mAb |
Product Details
Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.
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