Product Informations
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Product No.
BD-PA0009
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Synonyms
MEK2; MKK2; MAPKK2
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Product Name
MAP2K2 Mouse Monoclonal Antibody
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Category
493
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Gene Name
MAP2K2
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Recommended Applications
WB,ICC,FCM,Elisa
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Reactivity
Human,Mouse,Rat
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Storage Buffer
Ascitic fluid containing 0.03% New type preservative N.
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Immunogen
Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
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Dilution Ratio
WB 1:500-1:2000, ICC 1:200-1:1000, FCM 1:200-1:400, ELISA 1:10000
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Reference Molecular Weight
44kDa
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Shipping and Storage Conditions
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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Host
Mouse
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Isotype
IgG1
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Clone No.
7F5
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Lead Time
Three working days
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Clonality
Monoclonal
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Human Gene ID
5605
Picture
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Western blot analysis using MAP2K2 mouse mAb against PC-12 (1), Jurkat (2), Hela (3) and NIH/3T3 (4) cell lysate. |
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Immunofluorescence analysis of Hela cells using anti-MAP2K2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. |
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Flow cytometric analysis of Hela cells using anti-MAP2K2 mAb (green) and negative control (purple). |
Product Details
MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
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