Product Informations
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Product No.
BD-PA0016
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Synonyms
PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
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Product Name
PARP Mouse Monoclonal Antibody
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Category
493
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Gene Name
PARP-KLH
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Recommended Applications
WB,FCM,Elisa
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Reactivity
Human
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Storage Buffer
Ascitic fluid containing 0.03% New type preservative N.
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Immunogen
Synthetic peptide of human PARP, conjugated to KLH.
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Dilution Ratio
WB 1:500-1:2000, FCM 1:200-1:400, ELISA 1:10000
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Reference Molecular Weight
117kDa
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Shipping and Storage Conditions
4℃; -20℃ for long term storage. Avoid freeze/thaw cycles.
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Host
Mouse
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Isotype
IgG1
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Clone No.
7A10
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Lead Time
Three working days
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Clonality
Monoclonal
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Human Gene ID
142
Picture
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Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), Hela (3), Raji (4),THP-1 (5) and SW620 (6) cell lysate. |
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Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple). |
Product Details
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
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