Product Informations

• Product No. BD-PD246330
• Synonyms IGHG3 Protein, Human
• Product Name Human IgG3-Fc / IGHG3 Protein
• Category 466
• Shipping Method In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Reactivity human
• Storage Buffer Lyophilized from sterile PBS, pH 7.4 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information
• Reference Molecular Weight The recombinant human IgG3-Fc consists of 279 amino acids and has a predicted molecular mass of 31.2 kDa. As a result of glycosylation, the apparent molecular mass of IgG3-Fc is approximately 38 kDa in SDS-PAGE under reducing conditions.
• Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method
• Biological Activity Testing in progress
• Host HEK293 Cells
• Precautions A DNA sequence encoding the human IgG3 Fc region (P01860) (Glu 99-Lys 377) was expressed and purified.
• Background IGHG3 (Immunoglobulin Heavy Constant Gamma 3 (G3m Marker), also known as IgG3) is a Protein Coding gene. Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Murine immunoglobulin G (IgG) plays an important role in mediating protective immune responses to malaria. Diseases associated with IGHG3 include Heavy Chain Disease and Gamma Heavy Chain Disease. Among its related pathways are IL4-mediated signaling events and the Creation of C4 and C2 activators.
• Purification > 96 % as determined by SDS-PAGE
• Human Swissprot No. P01860

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Product Details