Q1: For cytokines, is species important? Or if the sequence homology is high, is the difference small? I need mouse cytokines, but you only have human ones. Some activity data show use in mouse cells, others don't.
Theoretically, as long as the sequence homology is high, the difference in activity will not be significant. For those with low homology, the dosage used will vary among different species. For example, in this cell of L929 mice, refer to R& As for the data of D, human TNFa Its activity in mice is about 4 to 5 times weaker than that of murine TNF-a, meaning its effect is not as good as that of murine TNF-a.
Q2: Why do we need to verify in mouse cells? There's no Human data.
The main reason for using mouse cells for verification is that human cells are relatively difficult to purchase, and well-known domestic and foreign brands all conduct tests using mouse L929
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